Synthesis of Certain New 6-Iodoquinazolines as Potential Antitubercular Agents
نویسندگان
چکیده
منابع مشابه
Synthesis of Isoxazoles and Cyanopyridines Bearing Benzo(b)thiophene Nucleus as Potential Antitubercular and Antimicrobial Agents
Isoxazole (2a-l) and cyanopyridine (3a-l) derivatives have been prepared by condensing chalcones (1a-l) with hydroxylamine hydrochloride and malononitrile respectively. While compounds 1a-l have been synthesized by the reaction of p-(3’-chloro-2’-benzo(b)thiophenoylamino)-acetophenone with different aldehydes. All the compounds were screened for their antitubercular and antimicrobial activities...
متن کاملSynthesis of Some 4-Thiazolidinone Derivatives as Antitubercular Agents
Substituted Schiff's bases 2a-o prepared by the treatment of 2-amino-4-(?-methoxyiminocarbomethoxymethyl)-thiazole 1 with different aromatic aldehydes, on cyclocondensation with mercaptoaceticacid and mercaptopropionicacid in dry benzene furnished desired thiazolidinones of type 3a-o and 4a-j, respectively. The structure of the compounds have been assigned on the basis of elemental analyses and...
متن کاملExploration of piperidinols as potential antitubercular agents.
Novel drugs to treat tuberculosis are required and the identification of potential targets is important. Piperidinols have been identified as potential antimycobacterial agents (MIC < 5 μg/mL), which also inhibit mycobacterial arylamine N-acetyltransferase (NAT), an enzyme essential for mycobacterial survival inside macrophages. The NAT inhibition involves a prodrug-like mechanism in which acti...
متن کاملsynthesis of isoxazoles and cyanopyridines bearing benzo(b)thiophene nucleus as potential antitubercular and antimicrobial agents
isoxazole (2a-l) and cyanopyridine (3a-l) derivatives have been prepared by condensing chalcones (1a-l) with hydroxylamine hydrochloride and malononitrile respectively. while compounds 1a-l have been synthesized by the reaction of p-(3’-chloro-2’-benzo(b)thiophenoylamino)-acetophenone with different aldehydes. all the compounds were screened for their antitubercular and antimicrobial activities...
متن کاملSynthesis of new 1,3-thiazoline-2-thiones as potential antimycobacterial agents
As a continuation of our efforts in developing new antimycobacterial agents, a series of new 1,3-thiazolidine-2-thione derivatives were synthesized. The chemical structures of the compounds were elucidated by FT-IR, 1H-NMR and Mass spectra. The analysis of theoretical toxicity risks,drug-likeness and drug-score for these series using Osiris program showed acceptable results.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Applied Sciences
سال: 2004
ISSN: 1812-5654
DOI: 10.3923/jas.2004.302.307